Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
Identifieur interne : 000947 ( Main/Exploration ); précédent : 000946; suivant : 000948Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
Auteurs : Youenn Jouan [France] ; Antoine Guillon [France] ; Loïc Gonzalez [France] ; Yonatan Perez [France] ; Chloé Boisseau [France] ; Stephan Ehrmann [France] ; Marion Ferreira [France] ; Thomas Daix [France] ; Robin Jeannet [France] ; Bruno François [France] ; Pierre-François Dequin [France] ; Mustapha Si-Tahar [France] ; Thomas Baranek [France] ; Christophe Paget [France]Source :
- The Journal of experimental medicine [ 1540-9538 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Antigènes CD (sang), Antigènes de différenciation des lymphocytes T (sang), Betacoronavirus (génétique), Cellules T invariantes associées aux muqueuses (immunologie), Cellules T invariantes associées aux muqueuses (métabolisme), Cellules T tueuses naturelles (immunologie), Cellules T tueuses naturelles (métabolisme), Cellules cultivées (MeSH), Cytokines (métabolisme), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Inflammation (immunologie), Inflammation (métabolisme), Lectines de type C (sang), Mâle (MeSH), Pandémies (MeSH), Phénotype (MeSH), Pneumopathie virale (immunologie), Pneumopathie virale (virologie), Pronostic (MeSH), Récepteur lymphocytaire T antigène, gamma-delta (métabolisme), Sujet âgé (MeSH), Syndrome de détresse respiratoire de l'adulte (immunologie), Syndrome de détresse respiratoire de l'adulte (virologie), Études prospectives (MeSH).
- MESH :
- génétique : Betacoronavirus.
- immunologie : Cellules T invariantes associées aux muqueuses, Cellules T tueuses naturelles, Infections à coronavirus, Inflammation, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- métabolisme : Cellules T invariantes associées aux muqueuses, Cellules T tueuses naturelles, Cytokines, Inflammation, Récepteur lymphocytaire T antigène, gamma-delta.
- sang : Antigènes CD, Antigènes de différenciation des lymphocytes T, Lectines de type C.
- virologie : Infections à coronavirus, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- Adulte d'âge moyen, Cellules cultivées, Femelle, Humains, Indice de gravité de la maladie, Mâle, Pandémies, Phénotype, Pronostic, Sujet âgé, Études prospectives.
English descriptors
- KwdEn :
- Aged (MeSH), Antigens, CD (blood), Antigens, Differentiation, T-Lymphocyte (blood), Betacoronavirus (genetics), Cells, Cultured (MeSH), Coronavirus Infections (immunology), Coronavirus Infections (virology), Cytokines (metabolism), Female (MeSH), Humans (MeSH), Inflammation (immunology), Inflammation (metabolism), Lectins, C-Type (blood), Male (MeSH), Middle Aged (MeSH), Mucosal-Associated Invariant T Cells (immunology), Mucosal-Associated Invariant T Cells (metabolism), Natural Killer T-Cells (immunology), Natural Killer T-Cells (metabolism), Pandemics (MeSH), Phenotype (MeSH), Pneumonia, Viral (immunology), Pneumonia, Viral (virology), Prognosis (MeSH), Prospective Studies (MeSH), Receptors, Antigen, T-Cell, gamma-delta (metabolism), Respiratory Distress Syndrome, Adult (immunology), Respiratory Distress Syndrome, Adult (virology), Severity of Illness Index (MeSH).
- MESH :
- chemical , blood : Antigens, CD, Antigens, Differentiation, T-Lymphocyte, Lectins, C-Type.
- genetics : Betacoronavirus.
- immunology : Coronavirus Infections, Inflammation, Mucosal-Associated Invariant T Cells, Natural Killer T-Cells, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- chemical , metabolism : Cytokines, Inflammation, Mucosal-Associated Invariant T Cells, Natural Killer T-Cells, Receptors, Antigen, T-Cell, gamma-delta.
- virology : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- Aged, Cells, Cultured, Female, Humans, Male, Middle Aged, Pandemics, Phenotype, Prognosis, Prospective Studies, Severity of Illness Index.
Abstract
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS.
DOI: 10.1084/jem.20200872
PubMed: 32886755
Affiliations:
- France
- Centre-Val de Loire, Limousin, Nouvelle-Aquitaine, Région Centre
- Limoges, Tours
- Université de Tours
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Boisseau, Chloe" sort="Boisseau, Chloe" uniqKey="Boisseau C" first="Chloé" last="Boisseau">Chloé Boisseau</name>
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<affiliation wicri:level="3"><nlm:affiliation>Service de pneumologie, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
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<author><name sortKey="Daix, Thomas" sort="Daix, Thomas" uniqKey="Daix T" first="Thomas" last="Daix">Thomas Daix</name>
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<author><name sortKey="Jeannet, Robin" sort="Jeannet, Robin" uniqKey="Jeannet R" first="Robin" last="Jeannet">Robin Jeannet</name>
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<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.</nlm:affiliation>
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<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.</nlm:affiliation>
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<region type="old region">Limousin</region>
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<author><name sortKey="Francois, Bruno" sort="Francois, Bruno" uniqKey="Francois B" first="Bruno" last="François">Bruno François</name>
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<author><name sortKey="Dequin, Pierre Francois" sort="Dequin, Pierre Francois" uniqKey="Dequin P" first="Pierre-François" last="Dequin">Pierre-François Dequin</name>
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<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
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<wicri:regionArea>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
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<author><name sortKey="Si Tahar, Mustapha" sort="Si Tahar, Mustapha" uniqKey="Si Tahar M" first="Mustapha" last="Si-Tahar">Mustapha Si-Tahar</name>
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</author>
<author><name sortKey="Baranek, Thomas" sort="Baranek, Thomas" uniqKey="Baranek T" first="Thomas" last="Baranek">Thomas Baranek</name>
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<country xml:lang="fr">France</country>
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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
</author>
<author><name sortKey="Paget, Christophe" sort="Paget, Christophe" uniqKey="Paget C" first="Christophe" last="Paget">Christophe Paget</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
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</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.</title>
<author><name sortKey="Jouan, Youenn" sort="Jouan, Youenn" uniqKey="Jouan Y" first="Youenn" last="Jouan">Youenn Jouan</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
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<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de chirurgie cardiaque et de réanimation chirurgicale cardio-vasculaire, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de chirurgie cardiaque et de réanimation chirurgicale cardio-vasculaire, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillon, Antoine" sort="Guillon, Antoine" uniqKey="Guillon A" first="Antoine" last="Guillon">Antoine Guillon</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Loic" sort="Gonzalez, Loic" uniqKey="Gonzalez L" first="Loïc" last="Gonzalez">Loïc Gonzalez</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
</author>
<author><name sortKey="Perez, Yonatan" sort="Perez, Yonatan" uniqKey="Perez Y" first="Yonatan" last="Perez">Yonatan Perez</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boisseau, Chloe" sort="Boisseau, Chloe" uniqKey="Boisseau C" first="Chloé" last="Boisseau">Chloé Boisseau</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
</author>
<author><name sortKey="Ehrmann, Stephan" sort="Ehrmann, Stephan" uniqKey="Ehrmann S" first="Stephan" last="Ehrmann">Stephan Ehrmann</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferreira, Marion" sort="Ferreira, Marion" uniqKey="Ferreira M" first="Marion" last="Ferreira">Marion Ferreira</name>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de pneumologie, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de pneumologie, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daix, Thomas" sort="Daix, Thomas" uniqKey="Daix T" first="Thomas" last="Daix">Thomas Daix</name>
<affiliation wicri:level="3"><nlm:affiliation>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jeannet, Robin" sort="Jeannet, Robin" uniqKey="Jeannet R" first="Robin" last="Jeannet">Robin Jeannet</name>
<affiliation wicri:level="3"><nlm:affiliation>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Francois, Bruno" sort="Francois, Bruno" uniqKey="Francois B" first="Bruno" last="François">Bruno François</name>
<affiliation wicri:level="3"><nlm:affiliation>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Limousin</region>
<settlement type="city">Limoges</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dequin, Pierre Francois" sort="Dequin, Pierre Francois" uniqKey="Dequin P" first="Pierre-François" last="Dequin">Pierre-François Dequin</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Si Tahar, Mustapha" sort="Si Tahar, Mustapha" uniqKey="Si Tahar M" first="Mustapha" last="Si-Tahar">Mustapha Si-Tahar</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
</author>
<author><name sortKey="Baranek, Thomas" sort="Baranek, Thomas" uniqKey="Baranek T" first="Thomas" last="Baranek">Thomas Baranek</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
</author>
<author><name sortKey="Paget, Christophe" sort="Paget, Christophe" uniqKey="Paget C" first="Christophe" last="Paget">Christophe Paget</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Tours, Faculté de Médecine de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université de Tours</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of experimental medicine</title>
<idno type="eISSN">1540-9538</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Antigens, CD (blood)</term>
<term>Antigens, Differentiation, T-Lymphocyte (blood)</term>
<term>Betacoronavirus (genetics)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Cytokines (metabolism)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Inflammation (immunology)</term>
<term>Inflammation (metabolism)</term>
<term>Lectins, C-Type (blood)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mucosal-Associated Invariant T Cells (immunology)</term>
<term>Mucosal-Associated Invariant T Cells (metabolism)</term>
<term>Natural Killer T-Cells (immunology)</term>
<term>Natural Killer T-Cells (metabolism)</term>
<term>Pandemics (MeSH)</term>
<term>Phenotype (MeSH)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Prognosis (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Receptors, Antigen, T-Cell, gamma-delta (metabolism)</term>
<term>Respiratory Distress Syndrome, Adult (immunology)</term>
<term>Respiratory Distress Syndrome, Adult (virology)</term>
<term>Severity of Illness Index (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Antigènes CD (sang)</term>
<term>Antigènes de différenciation des lymphocytes T (sang)</term>
<term>Betacoronavirus (génétique)</term>
<term>Cellules T invariantes associées aux muqueuses (immunologie)</term>
<term>Cellules T invariantes associées aux muqueuses (métabolisme)</term>
<term>Cellules T tueuses naturelles (immunologie)</term>
<term>Cellules T tueuses naturelles (métabolisme)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cytokines (métabolisme)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Inflammation (immunologie)</term>
<term>Inflammation (métabolisme)</term>
<term>Lectines de type C (sang)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Phénotype (MeSH)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Pronostic (MeSH)</term>
<term>Récepteur lymphocytaire T antigène, gamma-delta (métabolisme)</term>
<term>Sujet âgé (MeSH)</term>
<term>Syndrome de détresse respiratoire de l'adulte (immunologie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (virologie)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, CD</term>
<term>Antigens, Differentiation, T-Lymphocyte</term>
<term>Lectins, C-Type</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules T invariantes associées aux muqueuses</term>
<term>Cellules T tueuses naturelles</term>
<term>Infections à coronavirus</term>
<term>Inflammation</term>
<term>Pneumopathie virale</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Inflammation</term>
<term>Mucosal-Associated Invariant T Cells</term>
<term>Natural Killer T-Cells</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Distress Syndrome, Adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Inflammation</term>
<term>Mucosal-Associated Invariant T Cells</term>
<term>Natural Killer T-Cells</term>
<term>Receptors, Antigen, T-Cell, gamma-delta</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules T invariantes associées aux muqueuses</term>
<term>Cellules T tueuses naturelles</term>
<term>Cytokines</term>
<term>Inflammation</term>
<term>Récepteur lymphocytaire T antigène, gamma-delta</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes CD</term>
<term>Antigènes de différenciation des lymphocytes T</term>
<term>Lectines de type C</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Distress Syndrome, Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Phenotype</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Phénotype</term>
<term>Pronostic</term>
<term>Sujet âgé</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32886755</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1540-9538</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>217</Volume>
<Issue>12</Issue>
<PubDate><Year>2020</Year>
<Month>12</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of experimental medicine</Title>
<ISOAbbreviation>J. Exp. Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">e20200872</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1084/jem.20200872</ELocationID>
<Abstract><AbstractText>COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS.</AbstractText>
<CopyrightInformation>© 2020 Jouan et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jouan</LastName>
<ForeName>Youenn</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de chirurgie cardiaque et de réanimation chirurgicale cardio-vasculaire, Centre Hospitalier Régional Universitaire, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guillon</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gonzalez</LastName>
<ForeName>Loïc</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Perez</LastName>
<ForeName>Yonatan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boisseau</LastName>
<ForeName>Chloé</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ehrmann</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ferreira</LastName>
<ForeName>Marion</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de pneumologie, Centre Hospitalier Régional Universitaire, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daix</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jeannet</LastName>
<ForeName>Robin</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>François</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dequin</LastName>
<ForeName>Pierre-François</ForeName>
<Initials>PF</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Si-Tahar</LastName>
<ForeName>Mustapha</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baranek</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paget</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Tours, Faculté de Médecine de Tours, Tours, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Exp Med</MedlineTA>
<NlmUniqueID>2985109R</NlmUniqueID>
<ISSNLinking>0022-1007</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000945">Antigens, Differentiation, T-Lymphocyte</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C055855">CD69 antigen</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D037181">Lectins, C-Type</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016692">Receptors, Antigen, T-Cell, gamma-delta</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000945" MajorTopicYN="N">Antigens, Differentiation, T-Lymphocyte</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D037181" MajorTopicYN="N">Lectins, C-Type</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072336" MajorTopicYN="N">Mucosal-Associated Invariant T Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055611" MajorTopicYN="N">Natural Killer T-Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="Y">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016692" MajorTopicYN="N">Receptors, Antigen, T-Cell, gamma-delta</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>Disclosures: S. Ehrmann reported personal fees from Aerogen, grants from Fisher & Paykel, grants from Hamilton Medical, and personal fees from La Diffusion Technique Française outside the submitted work. M. Si-Tahar reported personal fees from Cynbiose Respiratory outside the submitted work. No other disclosures were reported.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>06</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>4</Day>
<Hour>17</Hour>
<Minute>10</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32886755</ArticleId>
<ArticleId IdType="pii">152073</ArticleId>
<ArticleId IdType="doi">10.1084/jem.20200872</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Centre-Val de Loire</li>
<li>Limousin</li>
<li>Nouvelle-Aquitaine</li>
<li>Région Centre</li>
</region>
<settlement><li>Limoges</li>
<li>Tours</li>
</settlement>
<orgName><li>Université de Tours</li>
</orgName>
</list>
<tree><country name="France"><region name="Centre-Val de Loire"><name sortKey="Jouan, Youenn" sort="Jouan, Youenn" uniqKey="Jouan Y" first="Youenn" last="Jouan">Youenn Jouan</name>
</region>
<name sortKey="Baranek, Thomas" sort="Baranek, Thomas" uniqKey="Baranek T" first="Thomas" last="Baranek">Thomas Baranek</name>
<name sortKey="Baranek, Thomas" sort="Baranek, Thomas" uniqKey="Baranek T" first="Thomas" last="Baranek">Thomas Baranek</name>
<name sortKey="Boisseau, Chloe" sort="Boisseau, Chloe" uniqKey="Boisseau C" first="Chloé" last="Boisseau">Chloé Boisseau</name>
<name sortKey="Boisseau, Chloe" sort="Boisseau, Chloe" uniqKey="Boisseau C" first="Chloé" last="Boisseau">Chloé Boisseau</name>
<name sortKey="Daix, Thomas" sort="Daix, Thomas" uniqKey="Daix T" first="Thomas" last="Daix">Thomas Daix</name>
<name sortKey="Daix, Thomas" sort="Daix, Thomas" uniqKey="Daix T" first="Thomas" last="Daix">Thomas Daix</name>
<name sortKey="Daix, Thomas" sort="Daix, Thomas" uniqKey="Daix T" first="Thomas" last="Daix">Thomas Daix</name>
<name sortKey="Dequin, Pierre Francois" sort="Dequin, Pierre Francois" uniqKey="Dequin P" first="Pierre-François" last="Dequin">Pierre-François Dequin</name>
<name sortKey="Dequin, Pierre Francois" sort="Dequin, Pierre Francois" uniqKey="Dequin P" first="Pierre-François" last="Dequin">Pierre-François Dequin</name>
<name sortKey="Dequin, Pierre Francois" sort="Dequin, Pierre Francois" uniqKey="Dequin P" first="Pierre-François" last="Dequin">Pierre-François Dequin</name>
<name sortKey="Ehrmann, Stephan" sort="Ehrmann, Stephan" uniqKey="Ehrmann S" first="Stephan" last="Ehrmann">Stephan Ehrmann</name>
<name sortKey="Ehrmann, Stephan" sort="Ehrmann, Stephan" uniqKey="Ehrmann S" first="Stephan" last="Ehrmann">Stephan Ehrmann</name>
<name sortKey="Ehrmann, Stephan" sort="Ehrmann, Stephan" uniqKey="Ehrmann S" first="Stephan" last="Ehrmann">Stephan Ehrmann</name>
<name sortKey="Ferreira, Marion" sort="Ferreira, Marion" uniqKey="Ferreira M" first="Marion" last="Ferreira">Marion Ferreira</name>
<name sortKey="Ferreira, Marion" sort="Ferreira, Marion" uniqKey="Ferreira M" first="Marion" last="Ferreira">Marion Ferreira</name>
<name sortKey="Francois, Bruno" sort="Francois, Bruno" uniqKey="Francois B" first="Bruno" last="François">Bruno François</name>
<name sortKey="Francois, Bruno" sort="Francois, Bruno" uniqKey="Francois B" first="Bruno" last="François">Bruno François</name>
<name sortKey="Francois, Bruno" sort="Francois, Bruno" uniqKey="Francois B" first="Bruno" last="François">Bruno François</name>
<name sortKey="Gonzalez, Loic" sort="Gonzalez, Loic" uniqKey="Gonzalez L" first="Loïc" last="Gonzalez">Loïc Gonzalez</name>
<name sortKey="Gonzalez, Loic" sort="Gonzalez, Loic" uniqKey="Gonzalez L" first="Loïc" last="Gonzalez">Loïc Gonzalez</name>
<name sortKey="Guillon, Antoine" sort="Guillon, Antoine" uniqKey="Guillon A" first="Antoine" last="Guillon">Antoine Guillon</name>
<name sortKey="Guillon, Antoine" sort="Guillon, Antoine" uniqKey="Guillon A" first="Antoine" last="Guillon">Antoine Guillon</name>
<name sortKey="Guillon, Antoine" sort="Guillon, Antoine" uniqKey="Guillon A" first="Antoine" last="Guillon">Antoine Guillon</name>
<name sortKey="Jeannet, Robin" sort="Jeannet, Robin" uniqKey="Jeannet R" first="Robin" last="Jeannet">Robin Jeannet</name>
<name sortKey="Jeannet, Robin" sort="Jeannet, Robin" uniqKey="Jeannet R" first="Robin" last="Jeannet">Robin Jeannet</name>
<name sortKey="Jeannet, Robin" sort="Jeannet, Robin" uniqKey="Jeannet R" first="Robin" last="Jeannet">Robin Jeannet</name>
<name sortKey="Jouan, Youenn" sort="Jouan, Youenn" uniqKey="Jouan Y" first="Youenn" last="Jouan">Youenn Jouan</name>
<name sortKey="Jouan, Youenn" sort="Jouan, Youenn" uniqKey="Jouan Y" first="Youenn" last="Jouan">Youenn Jouan</name>
<name sortKey="Jouan, Youenn" sort="Jouan, Youenn" uniqKey="Jouan Y" first="Youenn" last="Jouan">Youenn Jouan</name>
<name sortKey="Paget, Christophe" sort="Paget, Christophe" uniqKey="Paget C" first="Christophe" last="Paget">Christophe Paget</name>
<name sortKey="Paget, Christophe" sort="Paget, Christophe" uniqKey="Paget C" first="Christophe" last="Paget">Christophe Paget</name>
<name sortKey="Perez, Yonatan" sort="Perez, Yonatan" uniqKey="Perez Y" first="Yonatan" last="Perez">Yonatan Perez</name>
<name sortKey="Perez, Yonatan" sort="Perez, Yonatan" uniqKey="Perez Y" first="Yonatan" last="Perez">Yonatan Perez</name>
<name sortKey="Perez, Yonatan" sort="Perez, Yonatan" uniqKey="Perez Y" first="Yonatan" last="Perez">Yonatan Perez</name>
<name sortKey="Si Tahar, Mustapha" sort="Si Tahar, Mustapha" uniqKey="Si Tahar M" first="Mustapha" last="Si-Tahar">Mustapha Si-Tahar</name>
<name sortKey="Si Tahar, Mustapha" sort="Si Tahar, Mustapha" uniqKey="Si Tahar M" first="Mustapha" last="Si-Tahar">Mustapha Si-Tahar</name>
</country>
</tree>
</affiliations>
</record>
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